A VISTA on PD-1H

Mechanistic Assessment of PD-1H

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.

V-domain immunoglobulin suppressor of T-cell activation (VISTA) is a negative immune-checkpoint protein that suppresses T-cell responses. To determine whether VISTA synergizes with another immune-checkpoint, programmed death 1 (PD-1), this study characterizes the immune responses in VISTA-deficient, PD-1-deficient (KO) mice and VISTA/PD-1 double KO mice. Chronic inflammation and spontaneous act...

The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?

A combined blockade of V-domain Ig suppressor of T-cell activation (VISTA) and PD-1 is a promising new cancer treatment option, which was efficient in murine tumor models and is currently tested in first phase I studies. Here, we analyzed the VISTA expression in a large and well-characterized gastric cancer (GC) cohort on 464 therapy-naive GC samples and 14 corresponding liver metastases using ...

Core system event analysis on windows vista

Event Tracing for Windows (ETW) has been the key instrumentation technology on Windows platforms for years. Many core operating system components have been instrumented with ETW, providing a basis for system activity analysis and problem diagnosis for a number of developers and tools. The upcoming Windows Vista ® operating system contains many new events, in response to the growing need to diag...

Messenger Forensics on Windows Vista and Windows

The purpose of this study is to identify several areas of forensic interest within the Yahoo! Messenger application, which are of forensic significance. This study focuses on new areas of interest within the file structure of Windows Vista and Windows 7. One of the main issues with this topic is that little research has been previously conducted on the new Windows platforms. Previously conducte...